Name | o-Bromobenzenesulfonyl chloride |
Synonyms | 2-BROMOSULFONYL CHLORIDE o-Bromobenzenesulfonyl chloride 2-BROMOBENZENESULFONYL CHLORIDE 2-bromobeneze sulfonyl chloride O-BROMOBENZENESULFONYL CHLORIDE 2-Bromobenzenesulfonyl chloride 2-Bromobenzenesulphonyl Chloride 2-BROMOBENZENESULPHONYL CHLORIDE 2-BROMOBENZENE-1-SULFONYL CHLORIDE Benzenesulfonyl chloride, 2-bromo- |
CAS | 2905-25-1 |
InChI | InChI=1/C6H4BrClO2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H |
InChIKey | VFPWGZNNRSQPBT-UHFFFAOYSA-N |
Molecular Formula | C6H4BrClO2S |
Molar Mass | 255.52 |
Density | 1.7910 (estimate) |
Melting Point | 49-52 °C (lit.) |
Boling Point | 98-100°C (0.5 torr) |
Flash Point | 127-128°C/2.4mm |
Vapor Presure | 0.000974mmHg at 25°C |
Appearance | Yellow-like crystals |
Color | Slightly yellow |
BRN | 2692202 |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Sensitive | Moisture Sensitive |
Refractive Index | 1.591 |
Hazard Symbols | C - Corrosive |
Risk Codes | 34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 3261 8/PG 2 |
WGK Germany | 3 |
HS Code | 29049090 |
Hazard Note | Corrosive |
Hazard Class | 8 |
Packing Group | II |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
application | 2-bromobenzenesulfonyl chloride, also known as o-bromobenzenesulfonyl chloride, has been more and more widely used as an important organic intermediate. In addition to being used for the synthesis of bioactive insecticides, it is increasingly showing its potential application value in the field of new drug research, which can be used for the synthesis of angiotensin Ⅱ AT1/AT2 receptor antagonists, and the synthesis of endothelin receptor antagonists. |
preparation | add o-bromophenol (18.9g,0.1mol),75ml of water and 75ml of dichloromethane to a 250ml three-neck bottle, stir with chlorine gas, and react at 5-10 ℃ for 1h. The mixture is diluted with 300ml dichloromethane, then washed with cold 5% sodium bicarbonate solution (2 × 50ml), washed with water (3 × 100ml), dried with anhydrous magnesium sulfate, and concentrated to obtain yellow solid. M. p.50-51 ℃, yield: 90%. |